publications

NAD+ supplements

NAD+ plays a key role in many activities in the body with aging decline. Studies show that NAD+ levels drop almost 50% once we reach middle age, which increases the risk of accelerated aging and the development or progression of age-related disorders. Keeping NAD+ levels elevated, especially in later life, may help to slow down aspects of the aging process and keep our cells and organs healthy with each passing year.

Scientists have known about NAD+ for more than 100 years, NAD+ enables cells to generate cellular energy from the food, activate enzymes including PARPs and sirtuins. NAD+ has been shown to increase cellular metabolism and energy production, maintain healthy mitochondria and promote cellular repair.

Publications

The NAD Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

By: Canto, Carles; Houtkooper, Riekelt H.; Pirinen, Eija; Youn, Dou Y.; Oosterveer, Maaike H.; Cen, Yana; Fernandez-Marcos, Pablo J.; Yamamoto, Hiroyasu; Andreux, Penelope A.; Cettour-Rose, Philippe; et al.
Cell Metabolism (2012), 15(6), 838-847.

Nicotinamide Riboside is Uniquely and Orally Bioavailable in Mice and Humans

By: Trammell, Samuel A. J.; Schmidt, Mark S.; Weidemann, Benjamin J.; Redpath, Philip; Jaksch, Frank; Dellinger, Ryan W.; Li, Zhonggang; Abel, E. Dale; Migaud, Marie E.; Brenner, Charles.
Nature Communications (2016), 7, 12948.

Chronic Nicotinamide Riboside Supplementation is Well-tolerated and Elevates NAD in Healthy Middle-aged and Older Adults

By: Martens, Christopher R. ; Denman, Blair A.; Mazzo, Melissa R.; Armstrong, Michael L.; Reisdorph, Nichole; McQueen, Matthew B.; Chonchol, Michel; Seals, Douglas R.
Nature Communications (2018), 9(1), 1-11.

Effective Treatment of Mitochondrial Myopathy by Nicotinamide Riboside, a Vitamin B3

By: Khan, Nahid A.; Auranen, Mari; Paetau, Ilse; Pirinen, Eija; Euro, Liliya; Forsstroem, Saara; Pasila, Lotta; Velagapudi, Vidya; Carroll, Christopher J.; Auwerx, Johan; et al.
EMBO Molecular Medicine (2014), 6(6), 721-731.

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

By: Elhassan, Yasir S.; Kluckova, Katarina; Fletcher, Rachel S.; Schmidt, Mark S.; Garten, Antje; Doig, Craig L.; Cartwright, David M.; Oakey, Lucy; Burley, Claire V.; Jenkinson, Ned; et al.
Cell Reports (2019), 28(7), 1717-1728. e6.

Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice

By: Trammell, Samuel A. J.; Weidemann, Benjamin J.; Chadda, Ankita; Yorek, Matthew S.; Holmes, Amey; Coppey, Lawrence J.; Obrosov, Alexander; Kardon, Randy H.; Yorek, Mark A.; Brenner, Charles.
Scientific Reports (2016), 6, 26933.

The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease

By: Schoendorf, David C.; Ivanyuk, Dina; Baden, Pascale; Sanchez-Martinez, Alvaro; De Cicco, Silvia; Yu, Cong; Giunta, Ivana; Schwarz, Lukas K.; Di Napoli, Gabriele; Panagiotakopoulou, Vasiliki; et al.
Cell Reports (2018), 23(10), 2976-2988.

Nicotinamide Riboside – The Current State of Research and Therapeutic Uses

By: Mehmel, Mario; Jovanovic, Nina; Spitz, Urs.
Nutrients (2020), 12(6), 1616.

Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults

By: Conze, Dietrich; Brenner, Charles ; Kruger, Claire L.
Scientific Reports (2019), 9(1), 1-13.

Nicotinamide Riboside is a Major NAD Precursor Vitamin in Cow Milk

By: Trammell, Samuel A. J.; Yu, Liping; Redpath, Philip; Migaud, Marie E.; Brenner, Charles.
Journal of Nutrition (2016), 146(5), 957-963.

Nicotinamide Riboside, a Form of Vitamin B3, Protects Against Excitotoxicity-induced Axonal Degeneration

By: Vaur, Pauline; Brugg, Bernard; Mericskay, Mathias; Li, Zhenlin; Schmidt, Mark S.; Vivien, Denis; Orset, Cyrille; Jacotot, Etienne; Brenner, Charles; Duplus, Eric.

FASEB Journal (2017), 31(12), 5440-5453.

Safety Assessment of Nicotinamide Riboside, a Form of Vitamin B3

By: Conze, D. B.; Crespo-Barreto, J.; Kruger, C. L.
Human & Experimental Toxicology (2016), 35(11), 1149-1160.